Genetic diseases

Regenerative medicine can potentially offer treatment for monogenic diseases through the use of cell and gene therapies.

We possess strengths in developing and trialling treatments for diseases such as Mucopolysaccharidosis (MPS). We collaborate with the Centre for Genomic Medicine at the Manchester University NHS Foundation Trust, which represents an integrated and multidisciplinary grouping of clinical and basic scientists.

Our expertise

• Karen Cosgrove

  View Karen’s research profile.

  Karen’s research focuses on understanding pancreatic beta-cell development and function in order to develop new treatments for diseases including diabetes and congenital hyperinsulinism.

• Martin Baron

  View Martin’s research profile.

  Martin’s research focuses on understanding how regulation of Notch signalling shapes tissues and regulates tissue homeostasis.

• Martin Lowe

  View Martin’s research profile.

  Martin works on the molecular mechanisms of protein trafficking in the endocytic and secretory pathways. His work involves understanding the mechanisms that govern various genetic disorders, and finding better treatments for them.

• Neil Roberts

  View Neil’s research profile.

  Neil works on viral vector-mediated gene therapy pre-clinical trials for genetic diseases of the lower urinary tract.

• Adrian Woolf

  View Adrian’s research profile.

  Adrian’s work involves identifying the stage at which development goes wrong so that people are born with absent or malformed organs.

• Rachel Taylor

  View Rachel’s research profile.

  Rachel uses innovative systems biology approaches to develop a holistic understanding of the pathophysiology of ophthalmic disease in highly relevant cellular systems, for the identification of novel therapeutic molecules and/or treatment strategies.