Underpinning bioscience

We are associated with basic researchers who work towards understanding the fundamental molecular and cellular mechanisms involved in tissue repair and regeneration.

Our expertise

• Stuart Allan

  View Stuart’s research profile.

  Stuart’s research focuses on the molecular mechanisms mediating brain damage in cerebrovascular disease and designing regenerative therapies. He also explores potential treatment for neuro-inflammation post-stroke.

• Enrique Amaya

  View Enrique’s research profile.

  Enrique’s research concentrates on the mechanisms that trigger and sustain a regenerative response, especially during appendage and heart regeneration.

• Aravind Vijayaraghavan

  View Aravind’s research profile.

  Aravind’s research focuses on tissue scaffolds and biosensors based on graphene and related nanomaterials, understanding the fundamentals of interaction between bio-molecules and cells with nanomaterials.

• Martin Baron

  View Martin’s research profile.

  Martin’s research aims to understand how regulation of Notch signalling shapes tissues and regulates tissue homeostasis.

• Christopher Blanford

  View Christopher’s research profile.

  Christopher’s group study the synthesis of functional materials suitable for tissue engineering applications. They also use quartz crystal microbalance analyses and electrochemistry to probe and control protein adsorption.

• Cyrill Bussy

  View Cyrill’s research profile.

  Cyrill works on the interaction of nanomaterials with adult stem cells in vitro and in vivo niche.

• Giulio Cossu

  View Giulio’s research profile.

  Giulio’s group develops cell therapy protocols for muscular dystrophy and tests these protocols first in animal models and then in phase I/II clinical trials.

• Rania Deranieh

  Rania works on the development of cancer and human stem cell-derived 3D culture models (spheroids and organoids) to study the interaction of human cells with nanomaterials and to develop novel theranostics.

• Philip Day

  View Philip’s research profile.

  Philip works on quantitative integrative analyses of bioanalyses, pathway function/ mechanism analysis, microbiome and chronic inflammatory diseases, miniaturisation for single cell studies, role of biological heterogeneity, systems biology and synthetic biology applications.

• Karel Dorey

  View Karel’s research profile.

  Karel is elucidating the cellular and molecular mechanisms governing spinal cord regeneration in Xenopus with the goal to improve outcomes for people with spinal cord injuries. 

   

   

• Natalie Gardiner

  View Natalie’s research profile.

  By characterising changes in the nervous system in experimental diabetes, Natalie hopes to develop new protective/regenerative treatments for diabetic neuropathy.

• Shane Herbert

  View Shane’s research profile.

  Shane’s research focuses on the molecular and cellular mechanisms of angiogenesis.

• Nigel Hooper

  View Nigel’s research profile.

  Nigel is using human induced pluripotent stem cells differentiated to neurons, brain endothelial cells, pericytes and astrocytes, embedded in 3D hydrogel scaffolds to probe the molecular and cellular mechanisms underpinning neurodegenerative diseases.

• Susan Kimber

  View Susan’s research profile.

  Sue focuses on using human pluripotent stem cells for disease modelling and regenerative medicine. She is interested in human kidney and cartilage development and genetic disease.

• Svitlana Kurinna

  View Svitlana's research profile.

  Svitlana uses modified antisense oligonucleotides for efficient delivery, tracking, and downregulation of miRNAs in cultured primary human skin cells and in mouse wound healing model in vivo. She is establishing miRNA crosslinking and immunoprecipitation (miR-CLIP) to identify new RNAs regulating growth and differentiation of cells essential for the improvement of cutaneous regeneration. 

• Rachel Lennon

  View Rachel’s research profile.

  Rachel specialises in basement membrane assembly, maintenance and repair.

• Robert Lucas

  View Robert’s research profile.

  Robert applies his expertise in the mechanisms of photoreception to develop methods by which light can be used to remotely control cell physiology for regenerative medicine.

• Adam Reid

  View Adam’s research profile.

  Adam’s research compliments his clinical interests in plastic surgery, in particular surgical reconstruction following trauma. He is examining novel interventions in pre-clinical models of peripheral nerve injury.

• Joe Swift

  View Joe’s research profile.

  Joe works on understanding how chemical and mechanical signals from the cellular microenvironment control cell behaviour. Further information is available on the Wellcome Trust Centre for Cell-Matrix Research website.

• Andrew Thomas

  View Andrew’s research profile.

  Andrew specialises in surface spectroscopy, applicable to polymer/metal/metal oxide substrates and wound healing. He focuses on understanding peptide and protein interaction with non-biological materials on the molecular/nanoscale.

• Tao Wang

  View Tao’s research profile.

  Using iPSC disease models, Tao studies genetic small vessel disease and neurovascular interactions, and exploring biodegradable scaffolds for stem cell in situ differentiation and vascular regeneration, and functionalising nanomaterials for biomedical applications.

• Lu Shin Wong

  View Lu Shin’s research profile.

  Lu Shin’s research is related to the development of novel materials for the study and manipulation of cells for applications in regenerative medicine.